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Germline mutations in CDH1 are infrequent in women with early-onset or familial lobular breast cancers
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  • Published on:
    E-Cadherin (CDH1) exon deletion in lobular breast carcinoma
    • William G Newman, Senior lecturer
    • Other Contributors:
      • Kristen D Hadfield, Helen J McBurney, Claire Searle, Fiona Lalloo, D Gareth R Evans

    It was with great interest that we read the recent article by Schrader et al. on the low frequency of CDH1 mutations in early-onset and familial lobular breast cancer (1). As detailed by Schrader et al., the cancer syndrome hereditary diffuse gastric cancer (HDGC), in addition to a high risk of diffuse gastric cancer (DGC), is associated with an increased risk of lobular breast carcinoma, a specific histological subtype of...

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    Conflict of Interest:
    None declared.