Genetic loci associated with lipid concentrations and cardiovascular risk factors in the Korean population
- 1Division of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul, South Korea
- 2Division of Structural and Functional Genomics, Center for Genome Science, National Institute of Health, Seoul, South Korea
- Correspondence to Dr Hyun-Young Park, Department of Cardiovascular and Rare Diseases, Center for Biomedical Sciences, National Institute of Health, Seoul 122-701, South Korea;
- Received 8 May 2010
- Revised 2 August 2010
- Accepted 25 August 2010
- Published Online First 23 October 2010
Background Dyslipidaemia, a key risk factor for cardiovascular disease (CVD), is strongly influenced by genetic factors.
Objective To identify genetic factors affecting blood lipid concentrations and CVD risk factors in the Korean population by a candidate gene association analysis.
Methods 21 single nucleotide polymorphisms (SNPs) that have been reported as associated with lipid concentrations in people of European ancestry were selected and their associations with CVD risk factors in Korean populations assessed. Genotype data from 7616 subjects without diabetes or lipid-lowering drugs were obtained from the Korean Association Resource (KARE) project.
Results After adjustment for age and gender, five SNPs were identified that were associated with high-density lipoprotein-cholesterol (HDL-C; rs4420638: p=2.09×10-7), 11 SNPs with low-density lipoprotein-cholesterol (LDL-C; rs12654264: p=1.29×10-8) and eight SNPs with triglycerides (TG; rs4420638: p=1.80×10-6). Through analysis of multiple associations with lipid traits, after adjustment for age, gender, body mass index, smoking, alcohol consumption and hypertension, five SNPs (rs693, rs17321515, rs174547, rs688, rs4420638) were identified that were strongly associated with at least two of the following: HDL-C, LDL-C and TG. Of these, rs693, which lies in the APOB gene, was also significantly associated with the homoeostasis model assessment for insulin resistance (p=6.68×10-6) and γ-glutamyl transpeptidase (p=2.34×10-6), and rs174547, which lies in the FADS1 gene and was significantly associated with fasting plasma glucose (p=1.48×10-6).
Conclusion Several SNPs associated with lipid traits and CVD risk factors were identified. These findings may form the basis for further investigations to identify the causative polymorphisms in dyslipidaemia and CVD.
- cardiovascular disease
- single nucleotide polymorphisms
- cardiovascular medicine
- lipid disorders
- clinical genetics
Funding This work was supported by a grant from the Korea National Institute of Health intramural research grant 4800-4845-300-210 (2010-N63001-00).
Competing interests None.
Ethics approval This study was conducted with the approval of the Korea National Institute of Health.
Provenance and peer review Not commissioned; externally peer reviewed.