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What is paradominant inheritance?
  1. R Happle
  1. Correspondence to Dr R Happle, Department of Dermatology, University of Marburg, Deutschhaus-Str 9, 35033 Marburg, Germany; happle{at}med.uni-marburg.de

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Paradominance is a particular form of non-mendelian inheritance. This mode of transmission was proposed to explain why a mosaic phenotype that usually occurs sporadically, such as Becker naevus, may affect, by way of exception, several members of a family.1 Heterozygous individuals are, as a rule, phenotypically normal, which is why the gene can be transmitted unperceived through many generations. The trait only becomes manifest when postzygotic loss of heterozygosity (LOH) occurs at an early developmental stage, giving rise to a …

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