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J Med Genet 46:585-592 doi:10.1136/jmg.2007.056093
  • Original article

Epigenetic analysis of the critical region I for premature ovarian failure: demonstration of a highly heterochromatic domain on the long arm of the mammalian X chromosome

Table 1

Variation in 2MK4 in premature ovarian failure (POF) patients

Gene Primers 2MK4* AcH4*
1p35.3
RPA2 RPA2 F3/R3 1.47 1.11
SMPDL3B ASMLC F1/R1 0.55 1.34
SMPDL3B ASMLCF/R 0.53 0.86
FLJ10307 NM018LC-F2/R2 0.56 0.88
FLJ10307 NM018LCF/R 0.69 0.85
FLJ10307 NM018-F1/R1TRIS 0.56 1.06
EYA3 EYALC-F/R 0.41 1.44
EYA3 EYALC-F2/R2 1.16 1.61
PTAFR PTAFLC-F1/R1 0.89 1.11
PTAFR 29.5-F/R 0.94 0.84
DNAJC8 IPJC8-F1/R1 1.36 1.06
2q14.2
PTPN4 PTP-F2/R2 0.82 0.58
PTPN4 PTPLC-F3/R3 0.74 0.70
EPB4.1L5 EPBLC-F1/R1 2.87 0.73
EPB4.1L5 EPBLC-F/R 11.58 1.42
FAM11B IPFAM11B-F/R 0.67 0.76
FAM11B IPFAM-F2/R2 1.73 1.16
RALB 96.7-F/R 0.87 1.09
3p21
CGGBP1 IP CGGBP1 F/R 0.73 0.95
CGGBP1 CGGBP1LC-F2/R2BIS 0.55 1.16
CGGBP1 CGGBP1LC-F3/R3BIS 0.42 1.28
MGC26717 MGC267LC-F2/R2 0.65 1.20
MGC26717 IP MGC26717 F1/R1 0.54 0.69
MGC26717 MGC267LC-F3/R3 BIS 0.65 1.32
5q35
CNOT6 IP CC4L F1/CNOT6IP-R 1.13 1.08
MGAT1 IP MGAT1 F/R 1.94 0.97
MGAT1 MGAT1LC-F2/R2 2.63 1.50
MGAT1 MGAT1LC-F3/R3 1.70 0.90
  • *The normalised fold change values in each POF patient was divided by the average values of four controls.

  • 2MK4 and AcH4 were normalised for AcH3.

  • The values for genes showing 2MK4 alterations are in bold.

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