Table 6 Caspase-1, -4, and -5 somatic mutations in different cancers
| Caspase | Tumour type | Total case numbers | Cases with mutation | Mutation site | Nucleotide change (predicted amino acid change) |
| Caspase-1142 | Gastric carcinoma | 54 | 2 | Exon 7 (p10) | 1034 T>A (M345K) |
| Intron 2 | VS2-3C>A (unknown) | ||||
| Caspase-4142 | Colon carcinoma | 103 | 2 | Intron 6 | IVS6+9C>A (unknown) |
| Exon 3 (p20) | 346 G>T (R116I) | ||||
| Caspase-5142 | NSCLC (adenocarcinoma) | 60 | 1 | Exon 4 (p20) | 629TNA (L210Q) |
| Caspase-5142 | Colon carcinoma | 103 | 4 | Exon 2 (CARD domain) | 153_154delAA (frameshift after codon 51 and stop at codon 68) |
| Exon 2 (CARD domain) | 154dupA (frameshift after codon 51 and stop at codon 68) | ||||
| 5′-UTR | -21_-22AA (unknown) | ||||
| Intron 6 | IVS6+6T>A (unknown) | ||||
| Caspase-5142 | Gastric carcinoma | 54 | 9 | 5′-UTR (4 cases) | -21_-22AA (unknown) |
| Exon 2 (CARD domain) (3 cases) | 154delA (frameshift after codon 51 and stop at codon 77) | ||||
| Exon 2 (CARD domain) | 153_154delAA (frameshift after codon 51 and stop at codon 68) | ||||
| Caspase-5142 | Breast carcinoma | 60 | 1 | Exon 1 | 105T>C (N35N) |
