Table 2 Summary of the 15 loci analysed in discovery and replication cohorts
| Chromosome | Marker | Position | Allele | β GWA (SE) | p Values GWA | β replication (SE) | p Values replication | β combined (SE) | p Values combined | Locus |
| 1p35.2 | rs7514514 | 31180643 | G | −0.109 (0.025) | 1.30E−05 | 0.035 (0.030) | 3.30E−01 | −0.049 (0.019) | 1.45E−02 | PUM1* |
| 1p35.2 | rs12406355 | 31190045 | A | 0.089 (0.024) | 1.60E−04 | 0 (0.027) | 1.00E+00 | 0.05 (0.018) | 6.30E−03 | PUM1* |
| 1q42.13 | rs238102 | 227549771 | C | 0.08 (0.025) | 9.73E−05 | 0.027 (0.030) | 3.80E−01 | 0.059 (0.019) | 2.10E−03 | C1orf96§ |
| 1q42.13 | rs238099 | 227575528 | A | 0.068 (0.023) | 2.58E−04 | 0.006 (0.030) | 8.60E−01 | 0.045 (0.018) | 1.70E−02 | C1orf96§ |
| 1q42.13 | rs7549589 | 227586550 | A | 0.062 (0.024) | 1.38E−03 | −0.002 (0.034) | 9.70E−01 | 0.037 (0.018) | 5.70E−02 | C1orf96§ |
| 1q44 | rs3102458 | 242606491 | A | 0.086 (0.028) | 2.10E−03 | −0.002 (0.033) | 1.00E+00 | 0.045 (0.022) | 2.40E−02 | C1orf100* |
| 1q44 | rs3123710 | 242611441 | A | −0.076 (0.023) | 1.01E−03 | 0.015 (0.028) | 4.20E−01 | −0.041 (0.018) | 3.30E−02 | C1orf100* |
| 1q44 | rs3003211 | 242679607 | A | −0.082 (0.025) | 8.40E−04 | 0.018 (0.030) | 4.70E−01 | −0.042 (0.019) | 3.30E−02 | ADSS* |
| 2q22.2 | rs1376749 | 143683862 | G | −0.123 (0.032) | 1.10E−04 | −0.059 (0.040) | 1.49E−01 | −0.102 (0.025) | 6.20E−05 | ARHGAP15* |
| 2q22.2 | rs12993643 | 143749432 | G | −0.093 (0.025) | 1.80E−04 | −0.013 (0.030) | 6.60E−01 | −0.062 (0.019) | 1.32E−03 | ARHGAP15* |
| 2q22.2 | rs4662198 | 143764197 | C | −0.095 (0.028) | 6.00E−04 | −0.025 (0.035) | 4.70E−01 | −0.069 (0.022) | 1.50E−03 | ARHGAP15* |
| 2q33.1 | rs1036533 | 201105969 | G | −0.157 (0.044) | 3.90E−04 | −0.048 (0.058) | 6.10E−01 | −0.115 (0.035) | 8.90E−04 | SGOL2† |
| 2q33.1 | rs10497853 | 201183402 | A | −0.16 (0.045) | 4.30E−04 | −0.066 (0.057) | 2.50E−01 | −0.125 (0.036) | 1.03E−03 | AOX1* |
| 3p22–p21.3 | rs1858740 | 38413376 | G | −0.081 (0.023) | 3.40E−04 | 0.009 (0.028) | 8.30E−01 | −0.045 (0.018) | 1.34E−02 | XYLB* |
| 3p22–p21.3 | rs4407366 | 38496429 | A | −0.103 (0.023) | 8.80E−06 | 0.04 (0.033) | 2.60E−01 | −0.054 (0.019) | 6.50E−03 | ACVR2B* |
| 3p22–p21.3 | rs7374458 | 38506215 | C | −0.105 (0.023) | 5.20E−06 | 0.02 (0.028) | 4.80E−01 | −0.054 (0.018) | 4.00E−03 | ACVR2B‡ |
| 3p14.3 | rs3774601 | 53797933 | G | −0.1 (0.024) | 3.10E−05 | 0.049 (0.028) | 8.60E−02 | −0.038 (0.019) | 3.80E−02 | CACNA1D* |
| 3p14.3 | rs3774605 | 53805807 | G | −0.1 (0.024) | 3.70E−05 | 0.053 (0.028) | 6.00E−02 | −0.035 (0.018) | 5.70E−02 | CACNA1D* |
| 3p14.3 | rs3774609 | 53807943 | A | −0.092 (0.024) | 1.20E−04 | 0.04 (0.028) | 1.48E−01 | −0.036 (0.023) | 7.40E−02 | CACNA1D* |
| 4q31.21 | rs1907107 | 143449084 | A | 0.073 (0.023) | 3.40E−04 | −0.009 (0.026) | 7.40E−01 | 0.034 (0.018) | 4.90E−02 | INPP4B* |
| 4q31.21 | rs2635429 | 143463006 | G | 0.067 (0.023) | 2.72E−04 | −0.02 (0.027) | 4.80E−01 | 0.029 (0.018) | 1.01E−01 | INPP4B* |
| 4q31.21 | rs1497393 | 143493161 | G | −0.066 (0.023) | 1.48E−04 | 0.025 (0.028) | 3.70E−01 | −0.029 (0.018) | 1.10E−01 | INPP4B* |
| 8p23.1 | rs4841067 | 8784655 | A | 0.139 (0.032) | 1.90E−05 | 0.01 (0.038) | 8.30E−01 | 0.088 (0.025) | 5.70E−04 | MFHAS1* |
| 8p23.1 | rs11778913 | 8852300 | A | 0.069 (0.026) | 8.10E−03 | 0.057 (0.033) | 8.40E−02 | 0.067 (0.021) | 1.48E−03 | THEX1§ |
| 8p23.1 | rs11249943 | 9645273 | A | −0.084 (0.029) | 3.60E−03 | 0.021 (0.033) | 5.20E−01 | −0.037 (0.022) | 7.80E−02 | TNKS* |
| 8p23.1 | rs6989782 | 9647948 | G | −0.076 (0.025) | 2.52E−04 | −0.003 (0.030) | 8.80E−01 | −0.048 (0.019) | 1.14E−02 | TNKS* |
| 9q31.2 | rs1570504 | 110094630 | C | −0.107 (0.033) | 1.24E−03 | 0.016 (0.031) | 4.60E−01 | −0.055 (0.026) | 2.90E−02 | ACTL7B‡ |
| 9q31.2 | rs1535619 | 110094886 | A | −0.075 (0.031) | 1.50E−02 | 0.004 (0.037) | 9.10E−01 | −0.04 (0.024) | 8.30E−02 | ACTL7B‡ |
| 9q31.2 | rs7028041 | 110096538 | G | −0.109 (0.034) | 1.23E−03 | 0.017 (0.023) | 5.50E−01 | −0.05 (0.026) | 4.40E−02 | ACTL7B‡ |
| 13q31.3 | rs9301921 | 93432990 | A | 0.08 (0.031) | 5.25E−04 | 0.059 (0.037) | 1.06E−01 | 0.074 (0.024) | 2.20E−03 | GPC6* |
| 13q31.3 | rs1415736 | 93444937 | G | 0.081 (0.031) | 3.70E−04 | 0.061 (0.043) | 1.60E−01 | 0.075 (0.026) | 3.50E−03 | GPC6* |
| 14q22.2 | rs4898848 | 54266336 | A | 0.072 (0.024) | 4.53E−04 | −0.001 (0.028) | 8.00E−01 | 0.04 (0.018) | 2.90E−02 | SAMD4* |
| 14q22.2 | rs6572971 | 54280838 | G | 0.1 (0.032) | 7.90E−04 | −0.021 (0.039) | 6.00E−01 | 0.052 (0.025) | 4.80E−02 | SAMD4* |
| 14q22.2 | rs1957356 | 54288744 | G | 0.092 (0.029) | 9.65E−05 | 0.03 (0.033) | 3.90E−01 | 0.064 (0.022) | 2.70E−03 | SAMD4* |
| 16q24.2–q24.3 | rs17214677 | 82008463 | A | 0.111 (0.037) | 2.80E−03 | −0.074 (0.046) | 1.12E−01 | 0.038 (0.029) | 2.10E−01 | CDH13* |
| 16q24.2–q24.3 | rs11861722 | 82125547 | A | 0.124 (0.038) | 9.70E−04 | −0.098 (0.043) | 2.30E−02 | 0.021 (0.029) | 4.20E−01 | CDH13* |
| 16q24.2–q24.3 | rs9934005 | 82137699 | G | 0.088 (0.027) | 9.20E−04 | −0.028 (0.031) | 3.80E−01 | 0.034 (0.020) | 8.50E−02 | CDH13* |
| 16q24.2–q24.3 | rs12598842 | 82145455 | A | −0.059 (0.023) | 8.80E−03 | −0.007 (0.023) | 1.00E+00 | −0.038 (0.018) | 4.40E−02 | CDH13* |
| 18q12.2 | rs2162440 | 33468004 | G | −0.104 (0.029) | 2.50E−04 | −0.119 (0.035) | 1.08E−03 | −0.106 (0.022) | 2.60E−06 | BRUNOL4§ |
| 18q12.2 | rs7235755 | 33470259 | G | −0.104 (0.028) | 2.60E−04 | −0.114 (0.035) | 2.00E−03 | −0.103 (0.022) | 5.50E−06 | BRUNOL4§ |
| 18q12.2 | rs2217127 | 33475628 | C | −0.08 (0.025) | 1.30E−03 | −0.047 (0.035) | 2.20E−01 | −0.063 (0.020) | 2.10E−03 | BRUNOL4§ |
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GWA, genome wide association; SE, standard error.
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*Intron; †coding; ‡flanking 3′ UTR; §flanking 5′UTR.
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Values in bold represent the two associated variants.
