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Association of arginase 1 gene polymorphisms with the risk of myocardial infarction and common carotid intima–media thickness
  1. Julie Dumont1,
  2. Mahmoud Zureik1,
  3. Dominique Cottel1,
  4. Michèle Montaye1,
  5. Pierre Ducimetière2,
  6. Philippe Amouyel1,
  7. Thierry Brousseau1
  1. 1Inserm, U744, Lille, France; Institut Pasteur de Lille, Lille, France; Université de Lille 2, UMR-S744, Lille, France
  2. 2Inserm, U780, Villejuif, France; Paris-Sud, UMR-S780, France
  1. Correspondence to:
 Professor P Amouyel
 Inserm U744, Institut Pasteur de Lille, 1 rue du Professeur Calmette, BP 245, F-59019 Lille Cedex, France; Philippe.Amouyel{at}pasteur-lille.fr

Abstract

Background: Recently, it was suggested that arginase (ARG)1 plays an important role in atherogenesis. However, because of its complex functions depending on vascular cell type, its impact on atherogenesis remains unclear.

Objective: To evaluate the association between ARG1 polymorphisms and phenotypes related to atherosclerosis.

Methods: Among 10 ARG1 polymorphisms selected from databases, 4 single-nucleotide polymorphisms (rs2781666; rs2781667; rs2781668; rs17599586) were tested for association with myocardial infarction (MI) in a case–control study (350 cases vs 581 controls), and with common carotid artery (CCA) intima–media thickness (CCA-IMT) in an independent sample of 963 subjects (Etude du Vieillissement Artériel (EVA) study).

Results: The genotype distribution of the rs2781666 G/T polymorphism differed significantly between MI cases and controls (p = 0.005), and the risk of MI was consistently increased for both GT heterozygotes (OR (95% CI) 1.5 (1.1 to 2.0)) and TT homozygotes (OR (95% CI) 2.2 (1.1 to 4.4)). In the EVA study, the rs2781666 polymorphism was also associated with an increase in CCA-IMT (p = 0.010), a surrogate marker of MI.

Conclusions: The ARG1 rs2781666 polymorphism was consistently associated with MI and an increased CCA-IMT. These findings reinforce the hypothesis of a significant role of ARG1 in vascular pathophysiology.

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Footnotes

  • Competing interests: None.

  • Published Online First 16 March 2007

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