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Familial T-cell non-Hodgkin lymphoma caused by biallelic MSH2 mutations
  1. Richard H Scott1,
  2. Tessa Homfray2,
  3. Nicola L Huxter1,
  4. Sally G Mitton3,
  5. Ruth Nash4,
  6. Mike N Potter5,
  7. Donna Lancaster5,
  8. Nazneen Rahman1
  1. 1Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
  2. 2Department of Clinical Genetics, St George’s Hospital NHS Trust, London, UK
  3. 3Department of Paediatrics, St George’s Hospital NHS Trust, London, UK
  4. 4Department of Histopathology, St George’s Hospital NHS Trust, London, UK
  5. 5Paediatrics Unit, Royal Marsden Hospital NHS Trust, Sutton, Surrey, UK
  1. Correspondence to:
 Richard Scott
 Section of Cancer Genetics, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, UK, SM2 5NG; richard.scott{at}icr.ac.uk

Abstract

Familial non-Hodgkin lymphoma (NHL) is rare and in most cases, no underlying cause is identifiable. We report homozygous truncating mutations in the mismatch repair gene MSH2 (226C→T; Q76X) in three siblings who each developed T-cell NHL in early childhood. All three children had hyperpigmented and hypopigmented skin lesions.

Constitutional biallelic MSH2 mutations have previously been reported in five individuals, all of whom developed malignancy in childhood. Familial lymphoma has not been reported in this context or in association with biallelic mutations in the other mismatch repair genes MLH1, MSH6 or PMS2. In addition, hypopigmented skin lesions have not previously been reported in biallelic MSH2 carriers. Our findings therefore expand the spectrum of phenotypes associated with biallelic MSH2 mutations and identify a new cause of familial lymphoma. Moreover, the diagnosis has important management implications as it allows the avoidance of chemotherapeutic agents likely to be ineffective and mutagenic in the proband, and the provision of cascade genetic testing and tumour screening for relatives.

  • HNPCC, hereditary non-polyposis colorectal cancer
  • MMR, mismatch repair
  • MMR-D, mismatch repair deficiency
  • NF1, neurofibromatosis type 1
  • NHL, non-Hodgkin lymphoma
  • DNA mismatch repair
  • MSH2
  • non-Hodgkin’s lymphoma
  • hereditary non-polyposis colorectal cancer

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Footnotes

  • This work was supported by the Institute of Cancer Research (UK). RS is supported by a grant that forms part of the Michael and Betty Kadoorie Cancer Genetics Research Programme.

  • Competing interests: None declared.

  • Informed consent was obtained for publication of figure 2.

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