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Reply to Dr Raux et al.: Molecular diagnosis of autosomal dominant early onset Alzheimer’s disease: an update (J Med Genet 2005;42:793–5)
  1. A J Larner,
  2. M Doran
  1. Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Liverpool, UK
  1. Correspondence to:
 Dr A J Larner
 Cognitive Function Clinic, Walton Centre for Neurology and Neurosurgery, Lower Lane, Fazakerley, Liverpoo, L9 7LJ, UK; a.larner{at}thewaltoncentre.nhs.uk

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In their recent article, Dr Raux and colleagues1 report eight new presenilin-1 (PSEN1) mutations in autosomal dominant early onset Alzheimer’s disease (AD), four of which are said to be at codons not previously reported as mutant in AD (codons 214, 386, …

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