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MDM2 SNP309 accelerates colorectal tumour formation in women
  1. Gareth L Bond1,
  2. Chiara Menin3,
  3. Roberta Bertorelle3,
  4. Pia Alhopuro4,
  5. Lauri A Aaltonen4,
  6. Arnold J Levine1,2
  1. 1The Institute for Advanced Study, Princeton, New Jersey, USA
  2. 2The Cancer Institute of New Jersey, New Brunswick, New Jersey, USA
  3. 3Istituto Oncologico Veneto, IOV, Padova, Italy
  4. 4Department of Medical Genetics, Biomedicum, Helsinki, Finland
  1. Correspondence to:
 A Levine
 The Institute for Advanced Study, Einstein Drive, Princeton, New Jersey 08540-0631, USA; alevine{at}ias.edu

Abstract

Recent studies have shown that the G-allele of MDM2 SNP309 (T/G) in the p53 tumour suppressor pathway can accelerate tumorigenesis and alter the risk of various cancers in women and not in men. In this report, data are presented from two independent groups of patients that suggest that the G-allele of SNP309 accelerates colorectal tumour formation only in women, and that lend further support to the model that primarily female-specific hormones, such as oestrogen, could either directly or indirectly allow for the G-allele of SNP309 to accelerate tumour formation in women.

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Footnotes

  • This work was supported by The Simons Foundation, The Leon Levy Foundation, Ministero della Ricerca Scientifica e Tecnologica (FIRB ’01; PRIN ’03), Fondazione Cassa di Risparmio di Padova e Rovigo, and National Cancer Institute grants P01 CA 87497 and P01 CA 65930-7.

  • Competing interests: None declared.

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