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Intestinal permeability in families with Crohn’s disease

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A genetically impaired intestinal barrier function has long been suspected to be a predisposing factor for Crohn’s disease (CD). Recently, mutations of the capsase recruitment domain family, member 15 (CARD15), have been identified and associated with CD.

To test the association of CARD15 with an impaired intestinal barrier, the authors studied 128 …

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