rss
J Med Genet 42:529-539 doi:10.1136/jmg.2004.028118
  • Review

The genetic and molecular bases of monogenic disorders affecting proteolytic systems

  1. I Richard
  1. Correspondence to:
 Dr I Richard
 Généthon CNRS UMR8115, 1, rue de l’internationale, 91000 Evry, France; richardgenethon.fr
  • Received 12 October 2004
  • Accepted 9 December 2004
  • Revised 15 November 2004

Abstract

Complete and limited proteolysis represents key events that regulate many biological processes. At least 5% of the human genome codes for components of proteolytic processes if proteases, inhibitors, and cofactors are taken into account. Accordingly, disruption of proteolysis is involved in numerous pathological conditions. In particular, molecular genetic studies have identified a growing number of monogenic disorders caused by mutations in protease coding genes, highlighting the importance of this class of enzymes in development, organogenesis, immunity, and brain function. This review provides insights into the current knowledge about the molecular genetic causes of these disorders. It should be noted that most are due to loss of function mutations, indicating absolute requirement of proteolytic activities for normal cellular functions. Recent progress in understanding the function of the implicated proteins and the disease pathogenesis is detailed. In addition to providing important clues to the diagnosis, treatment, and pathophysiology of disease, functional characterisation of mutations in proteolytic systems emphasises the pleiotropic functions of proteases in the body homeostasis.

Footnotes

  • Competing interests: none declared

Free sample
This recent issue is free to all users to allow everyone the opportunity to see the full scope and typical content of JMG.
View free sample issue >>

Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.

Navigate This Article