Table 2
Identification of CNA origin by microarray differential expression analysis
| Cells | Deletion region* | Breakpoint | Predicted breakpoint | Pre-point prevalence** | Post-point prevalence†† | Odds ratio‡‡ | ||
|---|---|---|---|---|---|---|---|---|
| Locus† | Mb‡ | Locus§ | Mb¶ | |||||
| *Deletion regions are derived from karyotypes data that provided by Coriell Cell Repositories/NIGMS; †the expected breakpoint locus determined based on previous cytogenetic evaluation/total number of assessed loci for the specific chromosome; ‡the expected base pair location of the breakpoint/total base pairs on the specific chromosome; §point estimate (and bootstrap 95% confidence interval) of the ordered locus at which chromosomal deletion begins; ¶point estimate (and bootstrap 95% confidence interval) of the chromosomal location (in megabases from pter) at which chromosomal deletion begins; **prevalence of microarray declared decreases in gene expression for genes with transcription start sites p terminal to the estimated breakpoint; ††prevalence of microarray declared decreases in gene expression for genes with transcription start sites q terminal to the estimated breakpoint; ‡‡odds of declared underexpression in the post-breakpoint region relative to that in the pre-breakpoint region. | ||||||||
| GM03240 | 7q35→qter | 1342/1493 | 143.0/158.2 | 1354 (1327 to 1406) | 147.8 (142.5 to 150.2) | 8.6% | 35.3% | 5.76 |
| GM00870 | 9pter→p13 | 187/1185 | 33.2/136.3 | 112 (40 to 243) | 19.4 (5.5 to 35.1) | 26.8% | 9.7% | 3.41 |
| GM03047 | 10pter→p12 | 232/1221 | 29.1/134.8 | 224 (197 to 252) | 28.1 (26.6 to 32.6) | 29.5% | 7.2% | 5.37 |
