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J Med Genet 42:e6 doi:10.1136/jmg.2004.028514
  • Correspondence

Non-random transmission of mutant alleles to female offspring in BRCA carriers

Table 2

 Proportion of unaffected female first degree relatives of BRCA1/2 mutation carriers testing positive for the family mutation from all four studies

Age at testing Testing positive Testing negative Proportion positive
<30 102 76 57% (p = 0.2)
30–49 218 192 54%
50+ 47 112 30%
Total 367 380 49%

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