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  • Evidence for association between single nucleotide polymorphisms in T complex protein 1 gene and schizophrenia in the Chinese Han population

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Evidence for association between single nucleotide polymorphisms in T complex protein 1 gene and schizophrenia in the Chinese Han population
  1. M S Yang1,2,
  2. L Yu1,2,
  3. T W Guo1,2,
  4. S M Zhu3,
  5. H J Liu3,
  6. Y Y Shi2,
  7. N-F Gu4,
  8. G Y Feng4,
  9. L He1,2
  1. 1Institute of Nutrition Science, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yue Yang Road, Shanghai 200031, People’s Republic of China
  2. 2Bio-X Life Science Research Center, Shanghai Jiao Tong University, 1954 Hua Shan Road, Shanghai 200030, People’s Republic of China
  3. 3Brain Hospital, Ji Lin Province, People’s Republic of China
  4. 4Shanghai Institute of Mental Health, Shanghai, 200030, People’s Republic of China
  1. Correspondence to:
 Professor L He
 Bio-X Life Science Research Center, Shanghai Jiao Tong University, Hao Ran Building, 1954 Hua Shan Road, Shanghai 200030, People’s Republic of China; helinsjtu.edu.cn

https://doi.org/10.1136/jmg.2003.011023

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    Schizophrenia (MIM 181500) is a severe, common, and heterogeneous psychiatric disorder that affects 1% of the world’s population. The disorder is characterised by hallucinations, delusions, disorganised thoughts, and various cognitive and affective impairments. As a leading cause of psychiatric admissions, schizophrenia accounts for a considerable portion of healthcare expenditure and is a major public health concern.

    Family, twin, and adoption studies have shown that a genetic factor is associated with susceptibility to schizophrenia.1–4 The number and nature of genes that influence susceptibility to schizophrenic illness, as well as their interaction with environmental factors, are unknown. Despite decades of research on anatomical, physiological, and biochemical changes possibly associated with schizophrenia, insight into the aetiology is only fragmentary. Mapping of genes that contribute to the development of schizophrenic disorders by means of linkage and association studies may help identify and characterise causal factors.

    Although no single causative gene has been identified to date, several chromosomal loci with positive linkage results are under investigation as tentative susceptibility loci for schizophrenia, including chromosomes 6, 8, 10, 13, and 22 to remove obstacles of locus heterogeneity among sampled populations.5

    Cao et al first reported possible linkage to 6q21–22 in two independent American samples of patients with schizophrenia: at locus D6S474 using sibling pair analysis in 63 independent sibling pairs (p = 0.00018) and at D6S424, which is about 14 centimorgan (cM) near D6S474 in a second sample of 87 independent sibling pairs (p = 0.00095).6 The same group reported modest support for linkage to D6S424 in a third sample in 1999 that consisted of 54 American and Australian sibling pairs.7 In a study with combined samples (141 independent sibling pairs), they obtained a non-parametric likelihood of odds (LOD) score of 3.82 (p = 0.000014).7

    Several other studies also supported a susceptibility locus for schizophrenia on …

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    Footnotes

    • Funding: This work was supported by grants from the national 863 (2002BA711A070–1) and 973 (DOICB510304) Programs, the National Natural Science Foundation of China (30130250), and the Ministry of Education (10414).

    • Conflicts of interest: none declared.