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J Med Genet 41:e7 doi:10.1136/jmg.2003.010983
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No evidence of an association between the T16189C mtDNA variant and late onset dementia

Table 2

 T16189C allele frequency in the different sub-groups

Status 16189 allele status
(mean age, (sd),% male) Wild type allele T Mutant allele C % mutant 95% CI
CI, confidence interval; sd, standard deviation
Controls ϵ4/− 27 7 20.6 7.0–34.2
(76.8 yrs (9.7), 48%) non ϵ4 85 8 8.6 2.9–14.3
Total 112 15 11.8 6.2–17.4
Alzheimer’s Disease ϵ4/− 87 12 12.1 5.7–18.6
(79.0 yrs (8.8), 37%) non ϵ4 70 8 10.3 3.5–17.0
Total 157 20 11.3 6.6–16.0
Dementia with Lewy Bodies ϵ4/− 47 7 13.0 4.0–22.0
(78.4 yrs (7.3), 55%) non ϵ4 37 5 11.9 2.1–21.7
Total 84 12 12.5 5.9–9.1

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