Table 3
Estimated χ2 test for the most significant three marker combinations using TRANSMIT
| H | D15S214* | D15S508† | D15S182‡ | Obs | Exp | Var (Obs−Exp) | χ2 1 df | p value |
|---|---|---|---|---|---|---|---|---|
| Markers are shown in order. H, haplotypes for the combination D15S214/D15S508/D15S182; only haplotypes with frequencies above 0.03 are included. Obs, observed transmissions of haplotype to affected offspring; Exp, expected transmission under Mendelian inheritance; Var (Obs−Exp), variance of the difference between observed and expected transmissions; p values are two sided; corrected nominal alpha was set at 0.006 (corrected for nine tests) | ||||||||
| *Allele 3 = 262 bp; allele 6 = 268 bp | ||||||||
| †Allele 1 = 159 bp; allele 2 = 161 bp | ||||||||
| ‡Allele 4 = 283 bp; allele 6 = 287 bp; allele 7 = 289 bp | ||||||||
| 1 | 3 | 1 | 4 | 11.26 | 11.61 | 5.05 | 0.02 | ns |
| 2 | 3 | 2 | 4 | 7.74 | 8.76 | 4.71 | 0.22 | ns |
| 3 | 3 | 1 | 6 | 45.85 | 51.68 | 24.87 | 1.37 | 0.48 |
| 4 | 6 | 1 | 6 | 15.99 | 15.67 | 5.60 | 0.02 | ns |
| 5 | 3 | 2 | 6 | 31.84 | 32.01 | 10.08 | 0 | ns |
| 6 | 6 | 2 | 6 | 4.25 | 9.13 | 3.66 | 6.50 | 0.02 |
| 7 | 3 | 1 | 7 | 26.56 | 24.35 | 9.44 | 0.51 | 0.96 |
| 8 | 6 | 1 | 7 | 3.88 | 8.73 | 3.37 | 6.99 | 0.016 |
| 9 | 3 | 2 | 7 | 11.75 | 7.66 | 3.0 | 5.56 | 0.04 |
