Table 2
The relative frequency of mtDNA mutations causing LHON
| Pedigrees (n (%)) | ||
|---|---|---|
| Pathogenic mtDNA mutation | North east of England | Mackey et al3 |
| There was no significant difference between the frequency of the different groups in the north east of England and those of Mackey et al3 (χ2=4.67, p>0.25). | ||
| G11778A | 9 (56) | 110 (69) |
| G3460A | 5 (31) | 21 (13) |
| T14484C | 1 (6) | 23 (14) |
| All 3 “primary” | 15 (94) | 154 (97) |
| Non-primary | 1 (6) | 5 (3) |
| Total | 16 | 159 |
