Table 3
Known FA protein interactions
| Interacting proteins | Functional significance | Reference |
|---|---|---|
| FANCA with: | ||
| Alpha spectrin II | Scaffold protein involved in repair of interstrand cross links | 132, 133 |
| XPF | DNA repair endonuclease | 134 |
| SNX5 | Receptor trafficking between organelles | 135 |
| FANCC with: | ||
| GRP94 | Molecular chaperone | 136 |
| CDC2 | Cell cycle/apoptosis | 137, 138 |
| FAZF | Transcription regulator | 139 |
| Hsp70 | Apoptosis | 118 |
| GSTP1 | Apoptosis | 119 |
| STAT1 | Growth/differentiation | 140 |
| p450 reductase | Oxygen metabolism | 111 |
| FANCD2 with: | ||
| BRCA1 | DNA damage repair | 88 |
| ATM | Induces S phase checkpoint following ionising radiation | 15 |
| FANCG with: | ||
| CYP2E1 | Oxygen metabolism | 112 |
