Table 1
Chronology of disease among 37 patients with SIOD
| Age (years) at detection of | ||||||||
|---|---|---|---|---|---|---|---|---|
| Pedigree No | IUGR | Decreased growth | Recurrent infections | Renal disease | CNS symptoms | Death | Cause of death | Current age (years) |
| CMV, cytomegalovirus; EBV, Epstein-Barr virus; HSV, herpes simplex virus; IUGR, intrauterine growth retardation; NA, information not available; +, symptom present but age of onset not available. | ||||||||
| The data from patient 57, whose case history is presented in this manuscript, are shown in bold. | ||||||||
| Families with severe disease | ||||||||
| Patients born before 1990 | ||||||||
| 3 | + | 0 | NA | 3.5 | 5.6 | 8.5 | Stroke | |
| 4a | + | 1.5 | <3.5 | 3.5 | 8 | Renal failure | ||
| 4b | + | 2.5 | NA | 3 | 8 | Renal failure | ||
| 6 | + | 3.5 | + | 3.5 | 5 | Pulmonary embolism | ||
| 8 | + | 0 | + | 4 | 5.7 | Pneumonia | ||
| 9 | + | 5 | 8 | 10 | CMV encephalitis | |||
| 31 | + | 0 | 8 | 11 | 14 | Lymphoproliferative disease | ||
| 35 | + | 0 | 6 | 3 | 8 | Renal failure | ||
| 39 | − | 3 | 4 | 10 | 10 | 15 | Stroke | |
| 40 | + | 0.58 | 4 | 5 | 7 | Stroke | ||
| 57 | + | 0 | 0.25 | 5 | 8 | 20.0 | ||
| Patients born after 1990 | ||||||||
| 11 | − | 2.5 | 4 | 3 | 4 | 5 | Sepsis | |
| 21 | − | <5 | 9 | 10 | 12.9 | EBV infection | ||
| 22 | + | <5 | 6 | 8 | 14.6 | CMV infection | ||
| 23 | − | 0.5 | 3.75 | 4.14 | 8.7 | |||
| 24 | + | 0.5 | + | 5 | 9 | Stroke | ||
| 25 | + | 0.5 | + | 2 | <2 | 9.7 | ||
| 26 | − | 2.5 | <1 | <4 | 5.25 | 8 | Bone marrow failure | |
| 28 | − | 2 | + | 5 | 11.9 | |||
| 29 | + | 0 | 2 | 2 | <3 | 4 | Restrictive lung disease | |
| 30 | + | 0 | 5 | 5 | 5.7 | 10 | HSV pneumonitis | |
| 32 | − | 1.66 | 3 | 3.8 | 4.5 | Pulmonary embolism | ||
| 33a | + | 0 | 1.2 | 2.75 | Bone marrow failure | |||
| 33b | + | 1 | 2.25 | <1 | 3.7 | Stroke | ||
| 38 | + | 0 | 2 | 6.8 | + | 10.7 | Adenovirus | |
| 44 | + | 0 | 4 | 9.5 | ||||
| 47 | + | 0 | 4 | 10.7 | ||||
| 48 | − | 0 | 3 | 4 | 6.0 | |||
| 49 | + | 0 | <1 | 3 | 7.0 | |||
| 50 | + | 0 | 5 | 4.5 | 6.5 | |||
| 51 | + | 0 | 4.5 | 5 | 6.1 | |||
| 53 | − | 4 | 5–6 | 5 | 10.7 | |||
| Families with milder disease | ||||||||
| Patients born before 1990 | ||||||||
| 16 | + | 0 | 8 | 26.1 | ||||
| 18a | + | 13 | 11 | 36.5 | ||||
| 18b | + | 8 | 8 | 12 | Pulmonary oedema | |||
| 18c | + | 12 | 11 | 24.0 | ||||
| 27 | + | <3 | 10 | 20.0 | ||||
