Over-representation of PPARγ sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population

Xiao-Ping Zhou; Wendy M Smith; Oliver Gimm; Elisabetta Mueller; Xin Gao; Pasha Sarraf; Thomas W Prior; Christoph Plass; Andreas von Deimling; Peter McL Black; Allan J Yates; Charis Eng

doi:10.1136/jmg.37.6.410

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Original article

Over-representation of PPARγ sequence variants in sporadic cases of glioblastoma multiforme: preliminary evidence for common low penetrance modifiers for brain tumour risk in the general population

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	Abstract	Full	Pdf
Jun 2000	21	37	18
Jul 2000	8	27	10
Aug 2000	2	26	16
Sep 2000	1	16	10
Oct 2000	2	16	8
Nov 2000	3	11	5
Dec 2000	0	13	7
Jan 2001	2	8	7
Feb 2001	0	26	10
Mar 2001	1	8	4
Apr 2001	2	9	4
May 2001	1	12	5
Jun 2001	4	13	3
Jul 2001	1	8	1
Aug 2001	3	12	2
Sep 2001	4	13	1
Oct 2001	0	18	11
Nov 2001	1	10	2
Dec 2001	0	16	15
Jan 2002	1	10	0
Feb 2002	3	10	2
Mar 2002	1	7	6
Apr 2002	3	9	4
May 2002	3	15	1
Jun 2002	1	2	1
Jul 2002	4	1	1
Aug 2002	3	11	2
Sep 2002	0	5	1
Oct 2002	1	8	3
Nov 2002	1	11	1
Dec 2002	1	5	1
Jan 2003	0	3	2
Feb 2003	0	2	1
Mar 2003	1	8	1
Apr 2003	0	4	2
May 2003	3	8	3
Jun 2003	0	9	1
Jul 2003	12	33	0
Aug 2003	11	15	2
Sep 2003	14	17	8
Oct 2003	19	19	0
Nov 2003	23	20	3
Dec 2003	14	14	5
Jan 2004	17	75	1
Feb 2004	9	11	1
Mar 2004	13	14	2
Apr 2004	19	16	3
May 2004	38	43	8
Jun 2004	44	48	10
Jul 2004	45	55	7
Aug 2004	47	52	5
Sep 2004	31	39	6
Oct 2004	26	38	6
Nov 2004	12	33	11
Dec 2004	5	18	6
Jan 2005	8	22	5
Feb 2005	9	22	5
Mar 2005	7	15	7
Apr 2005	1	9	5
May 2005	11	16	7
Jun 2005	8	9	8
Jul 2005	3	3	1
Aug 2005	3	11	16
Sep 2005	10	17	10
Oct 2005	5	11	4
Nov 2005	7	8	6
Dec 2005	9	18	8
Jan 2006	10	11	8
Feb 2006	6	5	4
Mar 2006	2	11	0
Apr 2006	4	17	5
May 2006	2	8	4
Jun 2006	11	5	4
Jul 2006	7	3	5
Aug 2006	2	5	1
Sep 2006	3	4	7
Oct 2006	5	6	12
Nov 2006	5	4	2
Dec 2006	4	12	16
Jan 2007	5	14	7
Feb 2007	2	7	4
Mar 2007	4	4	4
Apr 2007	10	4	5
May 2007	11	10	6
Jun 2007	10	0	1
Jul 2007	6	6	6
Aug 2007	9	1	2
Sep 2007	10	4	7
Oct 2007	11	2	1
Nov 2007	5	0	3
Dec 2007	4	0	1
Jan 2008	3	4	2
Feb 2008	2	2	4
Mar 2008	8	2	2
Apr 2008	5	0	0
May 2008	6	4	1
Jun 2008	7	0	0
Jul 2008	11	1	0
Aug 2008	13	3	2
Sep 2008	13	5	7
Oct 2008	8	2	0
Nov 2008	18	3	2
Dec 2008	6	1	3
Jan 2009	8	1	1
Feb 2009	7	2	2
Mar 2009	13	3	1
Apr 2009	7	0	0
May 2009	9	0	1
Jun 2009	4	2	3
Jul 2009	8	2	2
Aug 2009	3	1	3
Sep 2009	7	1	0
Oct 2009	1	2	1
Nov 2009	8	2	0
Dec 2009	8	1	1
Jan 2010	4	0	3
Feb 2010	8	2	1
Mar 2010	6	1	0
Apr 2010	8	4	4
May 2010	2	0	0
Jun 2010	7	0	2
Jul 2010	6	5	2
Aug 2010	1	0	1
Sep 2010	12	1	0
Oct 2010	6	1	0
Nov 2010	7	2	0
Dec 2010	1	0	0
Jan 2011	5	3	1
Feb 2011	5	3	1
Mar 2011	1	6	3
May 2011	4	0	0
Jun 2011	4	0	0
Jul 2011	6	0	0
Aug 2011	8	1	0
Sep 2011	9	3	3
Oct 2011	5	0	0
Nov 2011	12	4	2
Dec 2011	9	7	3
Jan 2012	8	1	4
Feb 2012	11	5	2
Mar 2012	29	5	3
Apr 2012	8	3	1
May 2012	6	0	0
Jun 2012	30	3	5
Jul 2012	11	9	5
Aug 2012	5	7	2
Sep 2012	19	4	5
Oct 2012	15	10	8
Nov 2012	12	12	7
Dec 2012	10	5	4
Jan 2013	34	17	2
Feb 2013	12	4	4
Mar 2013	10	8	4
Apr 2013	12	4	3
May 2013	17	11	1
Jun 2013	5	3	0
Jul 2013	8	1	1
Aug 2013	14	3	1
Sep 2013	4	1	0
Oct 2013	1	1	4
Nov 2013	15	0	11
Dec 2013	10	4	1
Jan 2014	7	6	2
Feb 2014	6	11	2
Mar 2014	14	17	1
Apr 2014	29	12	4
May 2014	15	10	1
Jun 2014	9	10	3
Jul 2014	8	15	7
Aug 2014	5	14	2
Sep 2014	7	10	4
Oct 2014	6	15	1
Nov 2014	1	7	0
Dec 2014	3	2	4
Jan 2015	3	3	3
Feb 2015	3	3	3
Mar 2015	14	8	1
Apr 2015	13	4	2
May 2015	4	11	1
Jun 2015	5	4	2
Jul 2015	1	5	7
Aug 2015	2	6	1
Sep 2015	9	6	2
Oct 2015	5	2	2
Nov 2015	2	4	7
Dec 2015	4	14	1
Jan 2016	5	3	2
Feb 2016	11	4	2
Mar 2016	4	5	11
Apr 2016	1	2	3
May 2016	13	5	4
Jun 2016	6	4	1
Jul 2016	4	2	2
Aug 2016	5	5	1
Sep 2016	8	2	3
Oct 2016	11	2	5
Nov 2016	16	2	0
Dec 2016	7	2	1
Jan 2017	10	2	3
Feb 2017	1	4	0
Mar 2017	0	9	1
Apr 2017	1	8	3
May 2017	1	10	1
Jun 2017	9	10	3
Jul 2017	10	10	3
Aug 2017	10	10	0
Sep 2017	7	7	0
Oct 2017	14	12	1
Nov 2017	17	15	2
Dec 2017	9	9	3
Jan 2018	15	15	0
Feb 2018	15	15	5
Mar 2018	9	9	2
Apr 2018	15	11	1
May 2018	6	7	0
Jun 2018	15	13	1
Jul 2018	8	6	2
Aug 2018	13	11	4
Sep 2018	23	21	2
Oct 2018	78	78	3
Nov 2018	53	51	2
Dec 2018	66	66	3
Jan 2019	55	54	0
Feb 2019	48	48	3
Mar 2019	20	20	3
Apr 2019	3	1	5
May 2019	13	11	8
Jun 2019	7	8	2
Jul 2019	7	7	2
Aug 2019	7	7	3
Sep 2019	5	5	1
Oct 2019	4	4	4
Nov 2019	11	11	6
Dec 2019	17	15	7
Jan 2020	15	12	4
Feb 2020	7	7	5
Mar 2020	3	3	2
Apr 2020	8	6	1
May 2020	13	13	2
Jun 2020	61	61	3
Jul 2020	7	6	3
Aug 2020	5	5	5
Sep 2020	14	12	3
Oct 2020	15	16	5
Nov 2020	9	9	5
Dec 2020	11	11	3
Jan 2021	10	10	8
Feb 2021	7	7	5
Mar 2021	11	11	3
Apr 2021	9	7	8
May 2021	4	4	2
Jun 2021	10	10	0
Jul 2021	6	6	7
Aug 2021	10	6	6
Sep 2021	13	11	3
Oct 2021	5	4	18
Nov 2021	3	2	10
Dec 2021	24	22	4
Jan 2022	30	30	1
Feb 2022	55	53	1
Mar 2022	67	68	5
Apr 2022	54	54	4
May 2022	111	114	12
Jun 2022	49	49	3
Jul 2022	60	61	2
Aug 2022	99	98	5
Sep 2022	53	53	8
Oct 2022	37	34	7
Nov 2022	64	63	4
Dec 2022	56	56	2
Jan 2023	68	62	3
Feb 2023	72	72	1
Mar 2023	67	64	2
Apr 2023	61	61	5
May 2023	43	41	8
Jun 2023	53	53	0
Jul 2023	49	49	7
Aug 2023	52	52	2
Sep 2023	7	5	3
Oct 2023	8	8	1
Nov 2023	11	9	2
Dec 2023	23	2	0
Jan 2024	24	1	0
Feb 2024	30	3	0
Mar 2024	98	3	1
Total	3884	3815	986

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