Guidelines for a genetic risk based approach to advising women with a family history of breast cancer
- D M Ecclesa,
- D G R Evansb,
- J Mackay on behalf of the UK Cancer Family Study Group (UKCFSG)*c
- aWessex Clinical Genetics Service, Level G, Princess Ann Hospital, Coxford Road, Southampton SO16 5YA, UK, bClinical Genetics Service, St Mary's Hospital, Oxford Road, Manchester M13 OJH, UK, cDepartment of Oncology, Box 193, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK
- Dr Eccles
- Revised 21 September 1999
- Accepted 18 October 1999
Abstract
A family history of breast cancer has long been recognised as a significant risk factor for breast cancer. Quantifying that risk has been approached in publications and practically in a number of different ways. Increasingly regional genetics departments are called upon to help clarify guidelines for referral of women with a family history of breast cancer for genetic testing and to clarify breast cancer risk for women seeking early mammographic screening. This paper represents the current consensus guidelines from the UK Cancer Family Study Group and discusses some of the difficulties surrounding genetic risk estimation.
Footnotes
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* UKCFSG Steering Committee: Professor DT Bishop (Secretary), Professor J Burn (Chairman), Mrs P Chapman, Professor E R Maher, Dr D Easton, Dr D Eccles, Dr R Eeles, Dr P Hopwood, Dr R Houlston, Dr S V Hodgson (ICRF), Dr F Macdonald, Dr J Mackay, Professor B A J Ponder (CRC)
