Club foot, an adverse outcome of early amniocentesis: disruption or deformation?
- aDivision of Genetics, Department of Laboratory Medicine, The Credit Valley Hospital, 2200 Eglinton Avenue W, Mississauga, Ontario, Canada L5M 2N1, bGenetics Program, North York General Hospital and IODE Children’s Centre, North York, Ontario, Canada M2K 1E1, cService de Genetique Medicale, Hopital Sainte-Justine, Centre Hospitalier Universitaire Mere-Enfant, Montreal, Quebec, Canada, dDepartment of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada, eDepartment of Obstetrics and Gynecology, The Toronto Hospital, Toronto, Ontario, Canada, fUniversity of British Columbia Department of Obstetrics and Gynecology, Children’s and Women’s Health Centre, Vancouver, British Columbia, Canada
- Dr Farrell.
- Revised 18 May 1999
- Accepted 17 June 1999
Abstract
An association between the occurrence of club foot and early amniocentesis has been reported. The largest of these randomised studies was the Canadian Early and Mid-Trimester Amniocentesis Trial. Data describing the neonatal outcome, focusing on this association, are presented. Possible mechanisms for the association and the implications for the development of club foot are discussed.
