X linked severe mental retardation, craniofacial dysmorphology, epilepsy, ophthalmoplegia, and cerebellar atrophy in a large South African kindred is localised to Xq24-q27

Table 2

Two point lod scores for X chromosome loci v XLMR condition

Locus		Location		Recombination (θ)		θmax		Ζmax
Locus		Location		0.001	0.01	θmax		Ζmax		0.05	0.1	0.2	0.3
DXS996	Xp22.32
KAL 5′	Xp22.32	−8.67	−4.69	−2.01	−0.97	−0.14	0.14	0.36	1.70
DXS987	Xp22.31	−3.43	−1.46	−0.20	0.22	0.45	0.40	0.22	0.45
DXS7593	Xp22	−7.13	−4.40	−1.98	−0.97	−0.15	0.12	0.36	0.16
DXS989	Xp22.13	−3.22	−1.24	0.03	0.45	0.63	0.51	0.20	0.64
DXS451	Xp22.13
DXS992	Xp21.3	−6.83	−3.84	−1.78	−0.96	−0.26	0.01	0.39	0.07
DXS1110	Xp21.1	−3.71	−1.73	−0.41	0.06	0.37	0.38	0.25	0.40
DXS993	Xp11.4
MAOA	Xp11.4	−9.11	−5.13	−2.45	−1.39	−0.52	−0.16	0.46	0.00
DXS1003	Xp11.3	−3.93	−1.94	−0.59	−0.08	0.27	0.32	0.27	0.33
DXS255	Xp11.23
DXS991	Xp11.21	0.49	0.49	0.47	0.43	0.34	0.22	0.00	0.49
ARA	Xq12	−5.51	−2.54	−0.58	0.13	0.58	0.59	0.25	0.62
DXS983	Xq12
DXS566	Xq13.3	−9.90	−6.72	−3.70	−2.29	−0.99	−0.38	0.50	0.00
DXS986	Xq21.1	−3.72	−1.74	−0.43	0.05	0.35	0.36	0.25	0.38
DXS995	Xq21.1	−1.64	−0.66	−0.04	0.15	0.23	0.20	0.21	0.23
DXS1002	Xq21.31	−6.55	−3.56	−1.52	−0.71	−0.04	0.18	0.35	0.20
DXS990	Xq21.33	−4.47	−2.49	−1.15	−0.63	−0.20	−0.03	0.42	0.02
DXS101	Xq22.1	−10.51	−7.02	−4.08	−2.69	−1.31	−0.60	0.57	0.00
DXS424	Xq23	−0.67	0.31	0.90	1.05	1.00	0.76	0.13	1.06
DXS1001	Xq24	2.81	2.78	2.65	2.46	1.99	1.41	0.00	2.81
DXS425	Xq25	2.50	2.48	2.37	2.20	1.78	1.26	0.00	2.50
HPRT	Xq26.1	1.83	1.81	1.70	1.55	1.21	0.84	0.00	1.83
DXS984	Xq27.1	1.65	1.62	1.50	1.34	1.02	0.68	0.00	1.65
DXS548	Xq27.3	−1.10	−0.12	0.49	0.66	0.67	0.51	0.15	0.69
DXS1113	Xq28	−0.39	0.58	1.13	1.24	1.10	0.77	0.11	1.24
DXS8011	Xq28	−2.79	−0.82	0.42	0.82	0.95	0.76	0.18	0.96
DXS8103	Xq28	−0.34	0.62	1.14	1.21	1.04	0.74	0.10	1.21
p39	Xq28	−3.99	−2.00	−0.68	−0.19	0.16	0.21	0.28	2.12
DXS11O8	Xq28	2.34	2.30	2.12	1.90	1.42	0.94	0.00	2.35

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