Article Text

PDF

A new locus for non-syndromal, autosomal recessive, sensorineural hearing loss (DFNB16) maps to human chromosome 15q21-q22.
  1. D A Campbell,
  2. D P McHale,
  3. K A Brown,
  4. L M Moynihan,
  5. M Houseman,
  6. G Karbani,
  7. G Parry,
  8. A H Janjua,
  9. V Newton,
  10. L al-Gazali,
  11. A F Markham,
  12. N J Lench,
  13. R F Mueller
  1. Molecular Medicine Unit, St James's University Hospital, Leeds, UK.

    Abstract

    Non-syndromal, recessive deafness (NSRD) is the most common form of inherited deafness or hearing impairment in humans. NSRD is genetically heterogeneous and it has been estimated that as many as 35 different loci may be involved. We report the mapping of a novel locus for autosomal recessive, non-syndromal deafness (DFNB16) in three consanguineous families originating from Pakistan and the Middle East. Using multipoint analysis (HOMOZ/MAPMAKER) a maximum combined lod score of 6.5 was obtained for the interval D15S1039-D15S123. Recombination events and haplotype analysis define a 12-14 cM critical region between the markers D15S1039 and D15S155 on chromosome 15q15-q21.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.