Article Text

PDF

Diagnosis of a complex chromosomal rearrangement using fluorescent in situ hybridisation.
  1. R Wallerstein,
  2. L Gibas,
  3. C E Anderson,
  4. L Jackson
  1. Division of Medical Geńetics, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107-5563, USA.

    Abstract

    We report the use of fluorescent in situ hybridisation (FISH) to clarify a complex chromosomal rearrangement (CCR) carried by a woman presenting with recurrent miscarriages. CCRs are rare cytogenetic rearrangements involving three or more chromosomes, which can be difficult to interpret using routine cytogenetic studies with GTG banding. FISH was used to establish a correct interpretation of the maternal karyotype before amniocentesis in a present pregnancy.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.