Article Text

PDF

Report of a critical recombination further narrowing the TSC1 region.
  1. K S Au,
  2. J Murrell,
  3. A Buckler,
  4. S H Blanton,
  5. H Northrup
  1. Department of Pediatrics, University of Texas Medical School Houston 77030, USA.

    Abstract

    A large tuberous sclerosis multigenerational family segregating with markers on chromosome 9q from the TSC1 region was studied with a new highly polymorphic marker (designated A6) from the region. A critical affected person showed recombination with the marker, eliminating approximately 100 kilobases from the telomeric end of the critical region, which contains three genes and three to four additional exons for which the associated genes have not been delineated. This information serves to further the search for the TSC1 gene.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.