Article Text

PDF

Exclusion of one pedigree affected by adult onset primary open angle glaucoma from linkage to the juvenile glaucoma locus on chromosome 1q21-q31.
  1. D Avramopoulos,
  2. G Kitsos,
  3. E Economou-Petersen,
  4. M Grigoriadou,
  5. D Vassilopoulos,
  6. C Papageorgiou,
  7. K Psilas,
  8. M B Petersen
  1. Department of Genetics, Institute of Child Health, Athens, Greece.

    Abstract

    A locus for autosomal dominant juvenile onset primary open angle glaucoma (POAG) was recently assigned to chromosome region 1q21-q31. In the present study, a large Greek family with autosomal dominant adult onset POAG was investigated using microsatellite markers. Exclusion of linkage of the adult onset POAG gene to the region D1S194-D1S191 was obtained in this pedigree. Therefore, the data provide evidence that juvenile and adult onset POAG are genetically distinct disease entities.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.