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Assessment of Yqh translocations.
  1. J L Fernández,
  2. S Pereira,
  3. A Campos,
  4. V Goyanes
  1. Centro Oncológico de Galicia, Laboratorio de Genética, La Coruña, Spain.

    Abstract

    Two initially presumed Yqh translocations, one to Xp and another to 21p, were assessed by conventional banding procedures, 5-azacytidine treatment, electron microscopy, and fluorescence in situ hybridisation. While the Yqh nature of the heterochromatic block from Xp was confirmed, this was not the case with the 21ph+ variant. In conclusion, conventional banding techniques are insufficient to diagnose Y;G translocations.

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