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Mapping of the X linked form of hyper IgM syndrome (HIGM1)
  1. M Padayachee,
  2. R J Levinsky,
  3. C Kinnon,
  4. A Finn,
  5. C McKeown,
  6. C Feighery,
  7. L D Notarangelo,
  8. R W Hendriks,
  9. A P Read,
  10. S Malcolm
  1. Molecular Genetics Unit, Institute of Child Health, London.

    Abstract

    X linked immunodeficiency with hyperimmunoglobulinaemia M (HIGM1), which is characterised by agammaglobulinaemia together with excess IgM production reflecting an impairment of the immunoglobulin heavy chain class switch of B lymphocytes, has been mapped to Xq26. We report multipoint linkage data in six families with HIGM1 which show that the most likely position for the gene is close to HPRT with a maximum lod score of 4.89. The finding of recombinations between HIGM1 and both HPRT and DXS42 implies that HIGM1 is not allelic to X linked lymphoproliferative disease. These data will be useful in genetic counselling in families and will also be useful in testing candidate genes.

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