Article Text

PDF

Chromosomal localisation of a pseudoautosomal growth gene(s).
  1. T Ogata,
  2. C Petit,
  3. G Rappold,
  4. N Matsuo,
  5. T Matsumoto,
  6. P Goodfellow
  1. Human Molecular Genetics Laboratory, Imperial Cancer Research Fund, London.

    Abstract

    Although recent molecular studies in patients with sex chromosome aberrations are consistent with a growth gene(s) being present in the pseudoautosomal region (PAR), the precise location has not been determined. In this report, we describe a Japanese boy and his mother with an interstitial deletion in Xp22.3 and review the correlation between genotype and stature in six cases of partial monosomy of the PAR. The results indicate that the region from DXYS20 to DXYS15 is the critical region for the putative growth gene(s).

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.