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J Med Genet 1992;29:858-860 doi:10.1136/jmg.29.12.858
  • Research Article

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.

  1. M A Crocq,
  2. R Mant,
  3. P Asherson,
  4. J Williams,
  5. Y Hode,
  6. A Mayerova,
  7. D Collier,
  8. L Lannfelt,
  9. P Sokoloff,
  10. J C Schwartz
  1. Centre Hospitalier, Rouffach, France.

      Abstract

      Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

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