Article Text

PDF

Association between schizophrenia and homozygosity at the dopamine D3 receptor gene.
  1. M A Crocq,
  2. R Mant,
  3. P Asherson,
  4. J Williams,
  5. Y Hode,
  6. A Mayerova,
  7. D Collier,
  8. L Lannfelt,
  9. P Sokoloff,
  10. J C Schwartz
  1. Centre Hospitalier, Rouffach, France.

    Abstract

    Disturbances in dopamine neurotransmission have been postulated to underlie schizophrenia. We report data from two independent studies of a BalI polymorphism in the dopamine D3 receptor gene in patients with schizophrenia. In both studies, more patients than controls were homozygous (p = 0.005, p = 0.008). When pooled data were analysed, this difference was highly significant (p = 0.0001) with a relative risk of schizophrenia in homozygotes of 2.61 (95% confidence intervals 1.60-4.26).

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    Linked Articles