Article Text

PDF

Dystrophin expression and genotypic analysis of two cases of benign X linked myopathy (McLeod's syndrome).
  1. N D Carter,
  2. J E Morgan,
  3. A P Monaco,
  4. M S Schwartz,
  5. S Jeffery
  1. Department of Child Health, St George's Hospital Medical School, London.

    Abstract

    DNA extraction and Southern blot analysis of two cases of McLeod's syndrome showed restriction fragments identical to normal controls using probes from the Xp21 (1-2) region, in contrast to striking deletions found in two other McLeod phenotypes studied in the USA. The McLeod locus is adjacent to Duchenne muscular dystrophy (DMD) and dystrophin immunocytochemistry showed that expression is normal in muscle from the two McLeod cases in spite of the mild DMD-like myopathy.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.