Article Text

PDF

Polymorphic acetylation of sulphamethazine in a Zimbabwe population.
  1. C F Nhachi
  1. Department of Clinical Pharmacology, Godfrey Huggins School of Medicine, University of Zimbabwe, Harare.

    Abstract

    Sulphamethazine, 8 mg/kg body weight, was administered orally in tablet form to 100 healthy volunteers and total and free sulphamethazine were determined in the six hour urine sample. The bimodal population frequency distribution for percentage acetylated sulphamethazine showed 42 of the tested population to be fast and 58 to be slow acetylators, that is, an estimation of q = 0.72 +/- 0.3 as the frequency of the allele controlling slow acetylation. The study also revealed ample evidence that the assay of the drug in urine can be done in a significantly shorter time.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.