Article Text

PDF

Paternal inheritance of translocation chromosomes in a t(X;21) patient with X linked muscular dystrophy.
  1. V M Kean,
  2. H L Macleod,
  3. M W Thompson,
  4. P N Ray,
  5. C Verellen-Dumoulin,
  6. R G Worton

    Abstract

    A number of DNA probes from the short arm of the X chromosome have been used to study the inheritance of the translocation chromosomes in a girl with an X; autosome translocation and muscular dystrophy. The two translocation chromosomes were found to be derived from the father's single normal X chromosome, ruling out maternal inheritance of a pre-existent mutation and enhancing the concept that the de novo translocation is responsible for the dystrophic phenotype.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.