You are here

Article Text

Article menu
Download PDFPDF
Research Article
Reciprocal translocation between chromosomes 8 and 9 in atypical chronic myeloid leukaemia.
  1. D G Oscier,
  2. G J Mufti,
  3. A Gardiner,
  4. T J Hamblin

    Abstract

    A balanced translocation t(8;9) (p11;q34) was present in the peripheral blood, bone marrow, and spleen cells of a patient with Ph negative chronic myeloid leukaemia. Subsequent transformation into acute leukaemia was associated with the emergence of trisomy 8 and der(8)(8qter----cen----8p11::9q34----9qter). This is the third reported case of t(8;9) (p11;q34) and raises the question of the role of c-abl in the pathogenesis of this myeloproliferative disorder.

    https://doi.org/10.1136/jmg.22.5.398

    Statistics from Altmetric.com

      Request Permissions

      If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.