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J Med Genet 1985;22:361-366 doi:10.1136/jmg.22.5.361
  • Research Article

The genetic control of phenformin 4-hydroxylation.

  1. R R Shah,
  2. D A Evans,
  3. N S Oates,
  4. J R Idle,
  5. R L Smith

      Abstract

      Previously published results of phenformin 4-hydroxylation in 195 unrelated white British volunteers and 87 family members of 27 randomly selected probands have been subjected to genetic analysis. The results clearly show that about 9% of this population has a genetically determined defect in carrying out this oxidation reaction. The character for the defect is inherited in a Mendelian autosomal recessive fashion. The polymorphism shows a substantial degree of dominance.

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