Article Text

PDF

Spatial relationship of human X and Y chromosomes at somatic metaphase.
  1. D Dosik,
  2. R S Verma

    Abstract

    A total of 592 cells was examined from 38 normal humans who had either small or very large Y chromosomes. Chromosome identification was based on the QFQ technique. The distance between the X and Y chromosome was measured from centromere to centromere. The spatial distance between X and Y was significantly smaller when the Y was small as compared to a very large Y (p less than 0.05). The distance increased as the length of the Y chromosome increased and a significant correlation coefficient (r = 0.58) was found (p less than 0.05). It is concluded that the length of the Y chromosome appears to play a major role in the non-random distribution of X and Y at somatic metaphase. The size and XY relationship in aneuploidy resulting from paternal non-disjunction and in patients with XXY and XYY should be investigated.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.