Article Text

PDF

Translocation 21q22q in an infertile human male
  1. A C Chandley*,
  2. T B Hargreave,
  3. J M Fletcher*
  1. *The MRC Clinical and Population Cytogenetics Unit, Edinburgh EH4 2XU.
  2. Department of Surgery (Urology), Western General Hospital, the University of Edinburgh, Edinburgh EH4 2XU.†

    Abstract

    Details are given of a balanced 21q22q Robertsonian translocation ascertained through infertility in a phenotypically normal male. Chromosome analyses on the proband and his parents showed that the translocation arose as a new mutation. The patient was oligospermic and had a high frequency of morphological abnormalities in his spermatozoa. Meiotic investigations showed a chain trivalent in all primary spermatocytes examined at diakinesis/metaphase I. The testicular histology was normal.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.