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Two families with the Li-Fraumeni cancer family syndrome
  1. A D J Pearson**,
  2. A W Craft**,
  3. J M Ratcliffe†††,
  4. J M Birch†††,
  5. P Morris-Jones†††,
  6. D F Roberts**
  1. *The Department of Child Health, University of Newcastle upon tyne and Royal Victoria Infirmary, Newcastle upon Tyne
  2. *The Department of Human Genetics, Unversity of Newcastle upon tyne and Royal Victoria Infirmary, Newcastle upon Tyne
  3. The Department of Child Health, University of Manchester, Manchester.
  4. The Department of Epidemiology, University of Manchester, Manchester.
  5. The Department of Social Research, University of Manchester, Manchester.

    Abstract

    The first two families to be identified in the United Kingdom with the Li-Fraumeni syndrome of familial cancer are reported. The first family comprises breast carcinoma in the mother and adrenocortical carcinoma, medulloblastoma, and rhabdomyosarcoma in three of her four children, and the second family comprises breast carcinoma in the mother and adrenocortical carcinoma and rhabdomyosacrcoma in two of her three children. All three of the surviving children with malignancy, and one other who has recently died, possess the tissue type antigen B12.

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