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Predisposition to spina bifida: Search for a relation to maternal gastric acid secretion.
  1. P A Stanway,
  2. I M Samloff,
  3. C J Brace,
  4. J H Renwick

    Abstract

    The peak acid output of the stomach in a group of 71 mothers of spina bifida children and in 71 matched controls was estimated indirectly by the serum level of group I pepsinogens. The mean levels did not differ significantly, suggesting that the conjectured teratogen is not specially acid-labile. The variance was significantly higher in index subjects than in controls, but the interpretation of this finding is not clear.

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