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Down's syndrome and deletion of short arms of a G chromosome.
  1. G H Ballantyne,
  2. M I Parslow,
  3. A M Veale,
  4. D H Pullon

    Abstract

    A woman in a family in which a G group chromosome (No. 21) with deleted short arms (21p-) is present has passed this chromosome to an intellectually deficient son, a normal son, and a daughter with Down's syndrome. Another daughter is chromosomally and phenotypically normal. As in other reports that focus on a concurrence of Gp- chromosomes and Down's anomaly, the possibility is considered that this chromosomal variant may predispose to developmental abnormalities or to non-disjunction, or both.

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