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Haemoglobin H disease and β-thalassaemia: Clinical haematological and electrophoretic studies in a family from South Lebanon
  1. Munib J. Shahid,
  2. Farid P. Khouri,
  3. Itaf F. Sahli
  1. Departments of Internal Medicine and Clinical Pathology, American University of Beirut, Beirut, Lebanon

    Abstract

    A family is described in which four sibs are affected with haemoglobin H disease. To our knowledge, this is the first instance where this disorder has been encountered in the Lebanon. In fact only a few cases have so far been reported from the Arab world.

    All four sibs had typical haemoglobin H bands on electrophoretic examination, and characteristic intracorpuscular inclusion bodies were demonstrated in a variable proportion of their erythrocytes, as well as in cells from a younger sib and from the mother. The latter also had elevation of the Hb-A2 fraction, and it is suggested that the above family has a combination of α- and β-thalassaemia.

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    Footnotes

    • Deceased on 25 August 1973.

    • * Supported by research contract No. 371/0B from the International Atomic Energy Agency, Vienna.

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