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Haemoglobin F Malaysia: α2γ2 1 (NA1) Glycine→Cysteine; 136 Glycine
  1. Lie-Injo Luan Eng*,
  2. H. Kamuzora,
  3. H. Lehmann
  1. Institute for Medical Research, International Center for Medical Research (UC ICMR), Kuala Lumpur, Malaysia
  2. Medical Research Council Abnormal Haemoglobin Unit, University Department of Biochemistry, Addenbrooke's Hospital, Hills Road, Cambridge, England

    Abstract

    Structural studies of an abnormal haemoglobin found in a Chinese newborn but not in her parents, showed it to be a new γ-chain variant, Hb F Malaysia.

    The first residue of the γ-chain was Cys and not Gly, and the γ-chain was of the type in which residue 136 is Gly and not Ala.

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    Footnotes

    • * Present address: G. W. Hooper Foundation, University of California, San Francisco, California 94143, USA.

    • Seconded from the University of Dar-es-Salaam, Tanzania, as holder of a Commonwealth Academic Staff Scholarship.

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