J Med Genet. Published Online First: 8 June 2007. doi:10.1136/jmg.2007.050971
Letters to JMG |
The IRF5 polymorphism in type 1 diabetes
1 The McGill University Health Center, Canada
* To whom correspondence should be addressed. E-mail: constantin.polychronakos{at}mcgill.ca.
Accepted 22 May 2007
Abstract
The interferon regulatory factor 5 gene (IRF5) has been shown to play a crucial role in harmful immune responses by induction of proinflammatory cytokines. Functional genetic variants associated with increasd IRF5 expression of specific isoforms are associated with systemic lupus erythematosus (SLE) and it is possible that they may also predispose to other autoimmune disorders. We tested the association of two IRF5 SNPs, correlated with IRF5 expression and SLE risk, in 947 type 1diabetes (T1D) nuclear family trios by the transmission disequilibrium test. Our results suggest that the functional IRF5 variations do not confer obvious risk to T1D.
Keywords: genetic association, interferon regulatory factor 5, systemic lupus erythematosus, transmission disequilibrium test, type 1 diabetes
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text (Rapid PDF)
-
All Versions of this Article:
jmg.2007.050971v1
44/10/670 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
-
Author home page(s):
Constantin Polychronakos
Citing Articles
Google Scholar
PubMed
- PubMed Citation
- Articles by Qu, H.-Q.
- Articles by Polychronakos, C.
- Pubmed/NCBI databases
GeneGEO ProfilesHomoloGeneUniGeneSubstance via MeSHMedline Plus Health Information DiabetesDiabetes Type 1
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
