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The most recent version of this article was published on 1 March 2007

J Med Genet. Published Online First: 8 December 2006. doi:10.1136/jmg.2006.045732
Copyright © 2006 by the BMJ Publishing Group Ltd.

Review article

Challenges in the phenotypic characterization of patients in genetic studies of coronary artery disease

Albert Luo 1, Brian Jefferson 2, Mario Garcia 2, Geoffrey Ginsburg 3 and Eric J Topol 1*

1 Case Western, United States
2 Cleveland Clinic, United States
3 Duke, United States

* To whom correspondence should be addressed. E-mail: eric.topol{at}case.edu.

Accepted 12 November 2006


Abstract

Coronary artery disease and acute myocardial infarction are complex traits in which there has been recent research to identify the principal genes that engender susceptibility or provide protection. Although there has been exceptional progress in the technology that now allows genotyping of hundreds of thousands of single nucleotide polymorphisms in each individual, there remains a pattern of inconsistency in the studies performed to date, in part owing to the difficulties in defining cases and controls. In this paper, we review the salient issues to facilitate research in this important field.

Keywords: Atherosclerosis, Coronary Artery Disease, Genetics, Myocardial Infarction


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This article has been cited by other articles:

  • Damani, S. B., Topol, E. J. (2007). Future Use of Genomics in Coronary Artery Disease. J Am Coll Cardiol 50: 1933-1940 [Abstract] [Full Text]  
  • Ginsburg, G. S., Shah, S. H., McCarthy, J. J. (2007). Taking Cardiovascular Genetic Association Studies to the Next Level. J Am Coll Cardiol 50: 930-932 [Abstract] [Full Text]  

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