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Figure 1 Three patients of various ages with the cardiofaciocutaneous syndrome. The face is typical, with a broad forehead, bulbous tip of the nose, low-set ears, sparse scalp hair and absent eyebrows with ulerythema ophryogenes. The upper panel shows the same child at 10 months (left) and 6 years (right), describing the evolution of the phenotype. All of these children carry a BRAF mutation. Parents of patients gave written consent to publish these images.
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