LETTER TO JMG

A genome screen of families at high risk for Hodgkin lymphoma: evidence for a susceptibility gene on chromosome 4

L R Goldin¹, M L McMaster¹, M Ter-Minassian¹, S Saddlemire¹, B Harmsen², G Lalonde², M A Tucker¹

¹ Genetic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
² Westat Research Inc., Rockville, MD, USA

Correspondence to:
Correspondence to:
Dr L R Goldin
Genetic Epidemiology Branch, DCEG, NCI, 6120 Executive Blvd, 7236 MSC, Bethesda, MD 20892-7236, USA; goldinl@mail.nih.gov

Received 22 September 2004
Revised version received 4 November 2004

Accepted 4 November 2004

Keywords: Hodgkin lymphoma; chromosome 4; genomewide scan; high risk families

The first 150 words of the full text of this article appear below.

Hodgkin’s disease was recently designated Hodgkin lymphoma (HL) in the World Health Organization Classification.¹ The National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) population based registries estimate that 7900 new cases are diagnosed annually in the USA.² Clues to its aetiology have been suggested by the bimodal age distribution; higher risks in males, in people with higher socioeconomic status, and in smaller families; and occurrence of Epstein-Barr virus in HL tumour cells.³ The importance of genetic factors is indicated by reports of multiply affected families from case series,^4–6 a twin study,⁷ a case–control study,⁸ and population registry studies carried out in Utah,⁹ Denmark,¹⁰ Israel,¹¹ and Sweden.^12–14 We recently analysed data from registries in Sweden and Denmark and found significant familial aggregation of HL and other lymphoproliferative tumours.¹⁵ The relative risk for HL among first degree relatives of cases compared with controls was 3.1. Relative risks were higher in males . . . [Full text of this article]

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