© 2005 BMJ Publishing Group Ltd
LETTER TO JMG
Mapping of psoriasis to 17q terminus
1 Departments of Pediatrics and Medical Genetics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
2 Graduate Institute of Microbiology, College of Medicine, National Taiwan University, Taipei, Taiwan
3 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
4 Departments of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
5 Department of Pediatrics, Duke University Medical Center, Durham, NC, USA
Correspondence to:
Correspondence to:
Professor Yuan-Tsong Chen
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan; chen0010@ibms.sinica.edu.tw
Accepted 5 May 2004
Abbreviations: SNP, single nucleotide polymorphism; TBCD, tubulin specific chaperone d
Keywords: 17q terminus; genome-wide scan; PSORS2; psoriasis; tubulin-specific chaperone d gene
| The first 150 words of the full text of this article appear below. |
Psoriasis is a chronic, inflammatory, hyperproliferative disease of the skin, scalp, nails, and joints, with a prevalence of up to 2% in Caucasians1,2 but well under 1% in the Mongoloid races of the Far East.3 The disease varies in severity. Some patients display mild disease with isolated scaling erythematous plaques on the elbows or knees, whereas for others most of their cutaneous surface can be affected. At the cellular level, psoriasis is characterised by markedly increased epidermal proliferation and incomplete differentiation, elongation, dilation, and leakiness of the superficial plexus of dermal capillaries, and by a mixed inflammatory and immune cell infiltrate of the epidermis and papillary dermis.1,2 Dermal infiltrates comprised of T cells and macrophages typically appear in early lesions before epidermal changes.4 The therapeutic effect of immunosuppressive agents suggests psoriasis has a primary immune pathogenic basis.5
Susceptibility to the development of psoriasis is likely to have a significant genetic
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